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MGP004205

UniProt Annotations

Entry Information
Gene Nametripartite motif containing 22
Protein EntryTRI22_HUMAN
UniProt IDQ8IYM9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IYM9-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8IYM9-2; Sequence=VSP_012060; Note=No experimental confirmation available.;
DomainThe C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation.
DomainThe RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not necessary for nuclear localization.
FunctionInterferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648}.
InductionBy interferons alpha and beta. Up-regulated by p53/TP53. Dramatically induced by progesterone in MDA-MB-231- derived ABC28 cells and T47D cells. {ECO:0000269|PubMed:15064739, ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:19331816, ECO:0000269|PubMed:7797467}.
PathwayProtein modification; protein ubiquitination.
PtmAuto-ubiquitinated. {ECO:0000269|PubMed:18656448}.
Sequence CautionSequence=CAA57684.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305};
SimilarityBelongs to the TRIM/RBCC family. {ECO:0000305}.
SimilarityContains 1 B30.2/SPRY domain. {ECO:0000255|PROSITE- ProRule:PRU00548}.
SimilarityContains 1 B box-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00024}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular LocationCytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
SubunitInteracts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding. Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination. {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:19218198}.
Tissue SpecificityStrongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues. {ECO:0000269|PubMed:7797467}.
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