MGP Database

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MGP004228

Record overview

MGPD IDMGP004228
Gene ID10403
SpeciesHomo sapiens (Human)
Gene NameNDC80 kinetochore complex component
Gene Symbol NDC80
SynonymsHEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80;
Alternate nameskinetochore protein NDC80 homolog; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; kinetochore associated 2; kinetochore protein Hec1; kinetochore-associated protein 2; retinoblastoma-associated protein HEC;
Chromosome18
Map Location18p11.32
SummaryThis gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for NDC80

Proteins

kinetochore protein NDC80 homolog
Refseq ID:NP_006092
Protein GI:5174457
UniProt ID:O14777
mRNA ID:NM_006101
Length:642
RefSeq Status:
MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLC
EFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPHIVAALVWLIDCIKIHTAMKE
SSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK
ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELK
YARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSV
RTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHL
EEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE
 
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