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MGP004236

Record overview

MGPD IDMGP004236
Gene ID10423
SpeciesHomo sapiens (Human)
Gene NameCDP-diacylglycerol--inositol 3-phosphatidyltransferase
Gene Symbol CDIPT
SynonymsPIS; PIS1;
Alternate namesCDP-diacylglycerol--inositol 3-phosphatidyltransferase; PI synthase; PtdIns synthase; phosphatidylinositol synthase;
Chromosome16
Map Location16p11.2
EC Number2.7.8.11
SummaryPhosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
OrthologsView orthologs and multiple alignments for CDIPT

Proteins

CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1
Refseq ID:NP_006310
Protein GI:5453906
UniProt ID:O14735
mRNA ID:NM_006319
Length:213
RefSeq Status:
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSL
DVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARN
MAALDAADRAKKK
 
CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2
Refseq ID:NP_001273514
Protein GI:557440904
UniProt ID:O14735
mRNA ID:NM_001286585
Length:168
RefSeq Status:
MPDENIFLFVPNLIGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLC
AGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK
 
CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3
Refseq ID:NP_001273515
Protein GI:557440906
UniProt ID:A8K3L7
mRNA ID:NM_001286586
Length:148
RefSeq Status:
MLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPL
VGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK
 
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