MGP Database

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MGP004236

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol--inositol 3-phosphatidyltransferase
Protein EntryCDIPT_HUMAN
UniProt IDO14735
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O14735-1; Sequence=Displayed; Name=2; IsoId=O14735-2; Sequence=VSP_013618, VSP_013619, VSP_013620; Name=3; IsoId=O14735-3; Sequence=VSP_054767;
Biophysicochemical PropertiespH dependence: Optimum pH is 9.0. {ECO:0000269|PubMed:8110188}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269|PubMed:8110188};
Catalytic ActivityCDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. {ECO:0000269|PubMed:8110188}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:8110188}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:8110188}; Note=Divalent metal cations; Mn(2+) or Mg(2+). {ECO:0000269|PubMed:8110188};
Enzyme RegulationInhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri- phosphates.
FunctionCatalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188}.
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:8110188}.
Tissue SpecificityDetected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain. {ECO:0000269|PubMed:8110188}.
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