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MGP004240

Record overview

MGPD IDMGP004240
Gene ID10434
SpeciesHomo sapiens (Human)
Gene Namelysophospholipase I
Gene Symbol LYPLA1
SynonymsAPT1; LPL1; APT-1; LPL-I; hAPT1;
Alternate namesacyl-protein thioesterase 1; lysoPLA I; lysophospholipid-specific lysophospholipase;
Chromosome8
Map Location8q11.23
EC Number3.1.2.-
SummaryThis gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
OrthologsView orthologs and multiple alignments for LYPLA1

Proteins

acyl-protein thioesterase 1 isoform 1
Refseq ID:NP_006321
Protein GI:5453722
UniProt ID:O75608
mRNA ID:NM_006330
Length:230
RefSeq Status:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALI
DQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTF
KTYEGMMHSSCQQEMMDVKQFIDKLLPPID
 
acyl-protein thioesterase 1 isoform 2
Refseq ID:NP_001266285
Protein GI:525342559
UniProt ID:O75608
mRNA ID:NM_001279356
Length:196
RefSeq Status:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALI
DQEVKNGIPSNRIILGGFSQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
 
acyl-protein thioesterase 1 isoform 3
Refseq ID:NP_001266286
Protein GI:525342581
UniProt ID:O75608
mRNA ID:NM_001279357
Length:214
RefSeq Status:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILG
GFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMM
DVKQFIDKLLPPID
 
acyl-protein thioesterase 1 isoform 4
Refseq ID:NP_001266287
Protein GI:525342593
UniProt ID:O75608
mRNA ID:NM_001279358
Length:216
RefSeq Status:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALI
DQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQE
MMDVKQFIDKLLPPID
 
acyl-protein thioesterase 1 isoform 5
Refseq ID:NP_001266288
Protein GI:525342604
UniProt ID:O75608
mRNA ID:NM_001279359
Length:181
RefSeq Status:
MGRSLCRPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLR
ASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
 
acyl-protein thioesterase 1 isoform 6
Refseq ID:NP_001266289
Protein GI:525342616
UniProt ID:O75608
mRNA ID:NM_001279360
Length:166
RefSeq Status:
MNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDI
SILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
 
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