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MGP004240

UniProt Annotations

Entry Information
Gene Namelysophospholipase I
Protein EntryLYPA1_HUMAN
UniProt IDO75608
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75608-1; Sequence=Displayed; Name=2; IsoId=O75608-2; Sequence=VSP_009196; Note=No experimental confirmation available.;
Catalytic ActivityPalmitoyl-protein + H(2)O = palmitate + protein. {ECO:0000269|PubMed:22399288}.
Enzyme RegulationInhibited by palmostatin-B, leading to impair depalmitoylating of Ras. {ECO:0000269|PubMed:20418879}.
FunctionHydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. {ECO:0000269|PubMed:20418879, ECO:0000269|PubMed:22399288}.
Sequence CautionSequence=AAB88180.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the AB hydrolase superfamily. AB hydrolase 2 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000269|PubMed:11080636}.
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