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MGP004241

Record overview

MGPD IDMGP004241
Gene ID10437
SpeciesHomo sapiens (Human)
Gene Nameinterferon, gamma-inducible protein 30
Gene Symbol IFI30
SynonymsGILT; IP30; IP-30; IFI-30;
Alternate namesgamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30; interferon gamma-inducible protein 30 preproprotein; legumaturain;
Chromosome19
Map Location19p13.1
EC Number1.8.-.-
SummaryThe protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IFI30

Proteins

gamma-interferon-inducible lysosomal thiol reductase preproprotein
Refseq ID:NP_006323
Protein GI:29150261
UniProt ID:P13284
mRNA ID:NM_006332
Length:250
RefSeq Status:
MTLSPLLLFLPPLLLLLDVPTAAVQASPLQALDFFGNGPPVNYKTGNLYLRGPLKKSNAPLVNVTLYYEALCGGCRAFLIRELFPTWLLVMEILNVTLVP
YGNAQEQNVSGRWEFKCQHGEEECKFNKVEACVLDELDMELAFLTIVCMEEFEDMERSLPLCLQLYAPGLSPDTIMECAMGDRGMQLMHANAQRTDALQP
PHEYVPWVTVNGKPLEDQTQLLTLVCQLYQGKKPDVCPSSTSSLRSVCFK
 
sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2760
peptide sequence: 
MTLSPLLLFLPPLLLLLDVPTAAVQA

mat_peptide: 58..232
product: Gamma-interferon-inducible lysosomal thiol reductase
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P13284.3)
calculated_mol_wt: 19923
peptide sequence: 
NAPLVNVTLYYEALCGGCRAFLIRELFPTWLLVMEILNVTLVPYGNAQEQNVSGRWEFKCQHGEEECKFNKVEACVLDELDMELAFLTIVCMEEFEDMER
SLPLCLQLYAPGLSPDTIMECAMGDRGMQLMHANAQRTDALQPPHEYVPWVTVNGKPLEDQTQLLTLVCQLYQGK
 
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