MGP Database

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MGP004241

UniProt Annotations

Entry Information
Gene Nameinterferon, gamma-inducible protein 30
Protein EntryGILT_HUMAN
UniProt IDP13284
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=1200 uM for F(ab')2 fragment when denatured {ECO:0000269|PubMed:10639150}; KM=10 uM for F(ab')2 fragment {ECO:0000269|PubMed:10639150}; Note=Kinetic parameters shown are for mature enzyme.; pH dependence: Optimum pH is 4-5. {ECO:0000269|PubMed:10639150};
FunctionLysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). {ECO:0000250}.
InductionExpressed constitutively in antigen-presenting cells and induced by IFN-gamma in other cell types. {ECO:0000269|PubMed:3136170}.
MiscellaneousBoth precursor form and mature form have thiol reductase activity.
PtmN-glycosylated. Sugar chains contain mannose-6-phosphate. {ECO:0000269|PubMed:10639150, ECO:0000269|PubMed:10852914}.
PtmSynthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C- terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.
Sequence CautionSequence=AAA36105.1; Type=Erroneous termination; Positions=251; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAA36105.1; Type=Frameshift; Positions=146, 174; Evidence={ECO:0000305}; Sequence=AAA36105.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. N-terminal sequence identical to a region of chromosome 11.; Evidence={ECO:0000305}; Sequence=AAF04618.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. N-terminal sequence identical to a region of chromosome 11.; Evidence={ECO:0000305};
SimilarityBelongs to the GILT family. {ECO:0000305}.
Subcellular LocationSecreted. Lysosome.
SubunitDimer; disulfide-linked. {ECO:0000269|PubMed:10852914, ECO:0000269|PubMed:3136170}.
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