MGP Database

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MGP004245

Ontology/Pathway Information

Entrez Gene ID10451
Gene Namevav 3 guanine nucleotide exchange factor
Gene Symbol VAV3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005886 IEA:EnsemblCplasma membrane
GO:0005096 TAS:ProtIncFGTPase activator activity
GO:0005085 EXP:ReactomeFguanyl-nucleotide exchange factor activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0030676 IEA:EnsemblFRac guanyl-nucleotide exchange factor activity
GO:0005070 TAS:ProtIncFSH3/SH2 adaptor activity
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0050853 IMP:UniProtKBPB cell receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0006974 IMP:UniProtKBPcellular response to DNA damage stimulus
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 TAS:ReactomePinnate immune response
GO:0007229 IEA:EnsemblPintegrin-mediated signaling pathway
GO:0030032 IEA:EnsemblPlamellipodium assembly
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030593 IEA:EnsemblPneutrophil chemotaxis
GO:0030168 TAS:ReactomePplatelet activation
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0030890 IMP:UniProtKBPpositive regulation of B cell proliferation
GO:0045785 IEA:EnsemblPpositive regulation of cell adhesion
GO:0043547 EXP:GOCPpositive regulation of GTPase activity
GO:0043552 IEA:EnsemblPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0009967 TAS:GOCPpositive regulation of signal transduction
GO:0032314 IEA:EnsemblPregulation of Rac GTPase activity
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0042493 IMP:UniProtKBPresponse to drug
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0006906 IEA:EnsemblPvesicle fusion
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18266Axon guidance
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_264198EPH-ephrin mediated repulsion of cells
REACT_264068EPH-Ephrin signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_163701FCERI mediated MAPK activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_798Platelet activation, signaling and aggregation
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_11051Rho GTPase cycle
REACT_14797Signaling by GPCR
REACT_11044Signaling by Rho GTPases
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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