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MGP004245

UniProt Annotations

Entry Information

Gene Name	vav 3 guanine nucleotide exchange factor
Protein Entry	VAV3_HUMAN
UniProt ID	Q9UKW4
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=Alpha; IsoId=Q9UKW4-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9UKW4-2; Sequence=VSP_001820; Name=3; Synonyms=VAV3.1; IsoId=Q9UKW4-3; Sequence=VSP_041360, VSP_041361; Note=May be produced by alternative promoter usage.; Name=4; IsoId=Q9UKW4-4; Sequence=VSP_042359; Note=No experimental confirmation available.;
Function	Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adhesion. Does not affect integrin beta-1 (ITGB1)- mediated adhesion (By similarity). {ECO:0000250}.
Induction	Down-regulated by EGF and TGF-beta. {ECO:0000269\|PubMed:9705494}.
Interaction	Q13480:GAB1; NbExp=6; IntAct=EBI-297568, EBI-517684; P62993:GRB2; NbExp=5; IntAct=EBI-297568, EBI-401755; P08581:MET; NbExp=2; IntAct=EBI-297568, EBI-1039152; P27986:PIK3R1; NbExp=2; IntAct=EBI-297568, EBI-79464;
Ptm	Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=AAD03799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity	Contains 1 CH (calponin-homology) domain. {ECO:0000255\|PROSITE-ProRule:PRU00044}.
Similarity	Contains 1 DH (DBL-homology) domain. {ECO:0000255\|PROSITE-ProRule:PRU00062}.
Similarity	Contains 1 PH domain. {ECO:0000255\|PROSITE- ProRule:PRU00145}.
Similarity	Contains 1 phorbol-ester/DAG-type zinc finger. {ECO:0000255\|PROSITE-ProRule:PRU00226}.
Similarity	Contains 1 SH2 domain. {ECO:0000255\|PROSITE- ProRule:PRU00191}.
Similarity	Contains 2 SH3 domains. {ECO:0000255\|PROSITE- ProRule:PRU00192}.
Subunit	Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation. {ECO:0000269\|PubMed:11094073, ECO:0000269\|PubMed:12400014, ECO:0000269\|PubMed:16782872}.
Tissue Specificity	Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. {ECO:0000269\|PubMed:11094073, ECO:0000269\|PubMed:9705494}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/VAV3ID42782ch1p13.html";