MGP Database

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MGP004305

UniProt Annotations

Entry Information
Gene NameST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Protein EntrySIA7B_HUMAN
UniProt IDQ9UJ37
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCMP-N-acetylneuraminate + glycano-beta-D- galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N- acetyl-D-galactosaminyl)-glycoprotein.
MiscellaneousAberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST6GalNAc II; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_631";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC2";
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