MGP Database

MGP004313

Ontology/Pathway Information

Entrez Gene ID10628
Gene Namethioredoxin interacting protein
Gene Symbol TXNIP
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005758 IEA:EnsemblCmitochondrial intermembrane space
GO:0005634 IEA:EnsemblCnucleus
GO:0004857 IEA:EnsemblFenzyme inhibitor activity
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0007049 IEA:UniProtKB-KWPcell cycle
GO:0071228 IDA:UniProtKBPcellular response to tumor cell
GO:0045087 TAS:ReactomePinnate immune response
GO:0030216 IDA:UniProtKBPkeratinocyte differentiation
GO:0051782 IDA:UniProtKBPnegative regulation of cell division
GO:0000122 IEA:EnsemblPnegative regulation of transcription from RNA polymerase II promoter
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0048008 IEA:EnsemblPplatelet-derived growth factor receptor signaling pathway
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0006606 IEA:EnsemblPprotein import into nucleus
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0051592 IEA:EnsemblPresponse to calcium ion
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0032570 IEA:EnsemblPresponse to progesterone
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75808The NLRP3 inflammasome
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