MGP Database

MGP004313

Ontology/Pathway Information

Entrez Gene ID	10628
Gene Name	thioredoxin interacting protein
Gene Symbol	TXNIP
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005758	IEA:Ensembl	C	mitochondrial intermembrane space
GO:0005634	IEA:Ensembl	C	nucleus
GO:0004857	IEA:Ensembl	F	enzyme inhibitor activity
GO:0031625	IPI:UniProtKB	F	ubiquitin protein ligase binding
GO:0007049	IEA:UniProtKB-KW	P	cell cycle
GO:0071228	IDA:UniProtKB	P	cellular response to tumor cell
GO:0045087	TAS:Reactome	P	innate immune response
GO:0030216	IDA:UniProtKB	P	keratinocyte differentiation
GO:0051782	IDA:UniProtKB	P	negative regulation of cell division
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0035872	TAS:Reactome	P	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0048008	IEA:Ensembl	P	platelet-derived growth factor receptor signaling pathway
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0006606	IEA:Ensembl	P	protein import into nucleus
GO:0042127	IEA:Ensembl	P	regulation of cell proliferation
GO:0051592	IEA:Ensembl	P	response to calcium ion
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0009612	IEA:Ensembl	P	response to mechanical stimulus
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_6900	Immune System
REACT_75900	Inflammasomes
REACT_6802	Innate Immune System
REACT_75913	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75808	The NLRP3 inflammasome