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MGP004313

UniProt Annotations

Entry Information
Gene Namethioredoxin interacting protein
Protein EntryTXNIP_HUMAN
UniProt IDQ9H3M7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H3M7-1; Sequence=Displayed; Name=2; IsoId=Q9H3M7-2; Sequence=VSP_054401; Note=No experimental confirmation available.;
FunctionMay act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
InductionBy 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress. {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:8086474}.
PtmUbiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. {ECO:0000269|PubMed:20068034}.
SimilarityBelongs to the arrestin family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4. {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:21460850, ECO:0000269|PubMed:23519408}.
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