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MGP004323

Record overview

MGPD IDMGP004323
Gene ID10654
SpeciesHomo sapiens (Human)
Gene Namephosphomevalonate kinase
Gene Symbol PMVK
SynonymsPMK; PMKA; PMKASE; HUMPMKI;
Alternate namesphosphomevalonate kinase; hPMK;
Chromosome1
Map Location1q22
EC Number2.7.4.2;
SummaryThis gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for PMVK

Proteins

phosphomevalonate kinase
Refseq ID:NP_006547
Protein GI:5729980
UniProt ID:Q15126
mRNA ID:NM_006556
Length:192
RefSeq Status:
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGIS
QPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL
 
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