MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004323

UniProt Annotations

Entry Information
Gene Namephosphomevalonate kinase
Protein EntryPMVK_HUMAN
UniProt IDQ15126
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=25 uM for (R)-5-phosphomevalonate {ECO:0000269|PubMed:16519518, ECO:0000269|PubMed:9392419}; KM=0.26 mM for ATP {ECO:0000269|PubMed:16519518, ECO:0000269|PubMed:9392419}; Vmax=46.4 umol/min/mg enzyme with (R)-5-phosphomevalonate as substrate {ECO:0000269|PubMed:16519518, ECO:0000269|PubMed:9392419}; Vmax=52 umol/min/mg enzyme with ATP as substrate {ECO:0000269|PubMed:16519518, ECO:0000269|PubMed:9392419};
Catalytic ActivityATP + (R)-5-phosphomevalonate = ADP + (R)-5- diphosphomevalonate. {ECO:0000269|PubMed:8663599}.
InductionBy sterol. {ECO:0000269|PubMed:10191291}.
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:10191291}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityHeart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. {ECO:0000269|PubMed:8663599}.
  logo