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MGP004338

Record overview

MGPD IDMGP004338
Gene ID10715
SpeciesHomo sapiens (Human)
Gene Nameceramide synthase 1
Gene Symbol CERS1
SynonymsLAG1; UOG1; LASS1;
Alternate namesceramide synthase 1; longevity assurance (LAG1, S. cerevisiae) homolog 1; longevity assurance gene 1 protein homolog 1; protein UOG-1; upstream of GDF1;
Chromosome19
Map Location19p12
SummaryThis gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CERS1

Proteins

ceramide synthase 1 isoform 1
Refseq ID:NP_067090
Protein GI:11641421
UniProt ID:P27544
mRNA ID:NM_021267
Length:350
RefSeq Status:
MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMP
ESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHN
VGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFL
YIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKPLRNGLVKDKRF
 
ceramide synthase 1 isoform 2
Refseq ID:NP_937850
Protein GI:38176296
UniProt ID:P27544
mRNA ID:NM_198207
Length:337
RefSeq Status:
MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMP
ESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHN
VGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFL
YIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAE
 
ceramide synthase 1 isoform 3
Refseq ID:NP_001277194
Protein GI:594140567
UniProt ID:Q5XG75
mRNA ID:NM_001290265
Length:239
RefSeq Status:
MPESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRY
HNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYW
FLYIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAE
 
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