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MGP004338

UniProt Annotations

Entry Information
Gene Nameceramide synthase 1
Protein Entry
UniProt IDQ5XG75
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27544-1; Sequence=Displayed; Name=2; IsoId=P27544-2; Sequence=VSP_003049; Note=No experimental confirmation available.;
FunctionMay be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity). {ECO:0000250}.
MiscellaneousThis protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Subcellular LocationIsoform 1: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.
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