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MGP004340

UniProt Annotations

Entry Information
Gene Nameneuregulin 3
Protein EntryNRG3_HUMAN
UniProt IDP56975
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P56975-1; Sequence=Displayed; Name=2; IsoId=P56975-2; Sequence=VSP_021830; Name=3; Synonyms=FBNRG3; IsoId=P56975-3; Sequence=VSP_021828, VSP_021829; Name=4; IsoId=P56975-4; Sequence=VSP_035752;
Developmental StageIsoform 3 is expressed in fetal brain but not in other fetal tissues. {ECO:0000269|PubMed:16478787}.
DomainERBB receptor binding is elicited entirely by the EGF-like domain. {ECO:0000250}.
DomainThe cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity). {ECO:0000250}.
FunctionDirect ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269|PubMed:16478787, ECO:0000269|PubMed:9275162}.
PtmExtensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated. {ECO:0000250, ECO:0000269|PubMed:16478787}.
PtmProteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
SimilarityBelongs to the neuregulin family. {ECO:0000305}.
SimilarityContains 1 EGF-like domain. {ECO:0000255|PROSITE- ProRule:PRU00076}.
Subcellular LocationIsoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
Subcellular LocationNeuregulin-3: Secreted {ECO:0000250}.
Subcellular LocationPro-neuregulin-3, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.
SubunitInteracts with ERBB4. {ECO:0000269|PubMed:10867024}.
Tissue SpecificityHighly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
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