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MGP004363

UniProt Annotations

Entry Information
Gene NameSEC24 family member A
Protein EntrySC24A_HUMAN
UniProt IDO95486
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95486-1; Sequence=Displayed; Name=2; IsoId=O95486-2; Sequence=VSP_029571, VSP_029572; Note=No experimental confirmation available.;
FunctionComponent of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
Sequence CautionSequence=CAA10334.1; Type=Frameshift; Positions=68; Evidence={ECO:0000305};
SimilarityBelongs to the SEC23/SEC24 family. SEC24 subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}.
SubunitCOPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2. {ECO:0000269|PubMed:20427317}.
Tissue SpecificityExpressed in fibroblasts, hepatocytes, and lymphocytes.
Web ResourceName=Wikipedia; Note=COPII entry; URL="http://en.wikipedia.org/wiki/COPII";
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