MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004392

UniProt Annotations

Entry Information
Gene Namelymphatic vessel endothelial hyaluronan receptor 1
Protein EntryLYVE1_HUMAN
UniProt IDQ9Y5Y7
SpeciesHuman
Comments
Comment typeDescription
FunctionLigand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269|PubMed:10037799}.
PtmO-glycosylated. {ECO:0000250}.
SimilarityContains 1 Link domain. {ECO:0000255|PROSITE- ProRule:PRU00323}.
Subcellular LocationMembrane {ECO:0000269|PubMed:10037799}; Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface.
SubunitHomodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN (By similarity). {ECO:0000250}.
Tissue SpecificityMainly expressed in endothelial cells lining lymphatic vessels. {ECO:0000269|PubMed:10037799}.
  logo