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MGP004425

Record overview

MGPD IDMGP004425
Gene ID10993
SpeciesHomo sapiens (Human)
Gene Nameserine dehydratase
Gene Symbol SDS
SynonymsSDH;
Alternate namesL-serine dehydratase/L-threonine deaminase; L-serine ammonia-lyase; L-serine deaminase; L-serine dehydratase; L-threonine dehydratase; TDH;
Chromosome12
Map Location12q24.13
EC Number4.3.1.17
SummaryThis gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SDS

Proteins

L-serine dehydratase/L-threonine deaminase
Refseq ID:NP_006834
Protein GI:33469958
UniProt ID:P20132
mRNA ID:NM_006843
Length:328
RefSeq Status:
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLK
NEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHS
FHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVV
IVCGGSNISLAQLRALKEQLGMTNRLPK
 
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