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MGP004425

UniProt Annotations

Entry Information
Gene Nameserine dehydratase
Protein EntrySDHL_HUMAN
UniProt IDP20132
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=23 mM for serine {ECO:0000269|PubMed:18342636}; KM=31 mM for threonine {ECO:0000269|PubMed:18342636};
Catalytic ActivityL-serine = pyruvate + NH(3). {ECO:0000269|PubMed:18342636}.
Catalytic ActivityL-threonine = 2-oxobutanoate + NH(3). {ECO:0000269|PubMed:18342636}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PathwayCarbohydrate biosynthesis; gluconeogenesis.
SimilarityBelongs to the serine/threonine dehydratase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:14646100}.
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