MGP Database

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MGP004431

UniProt Annotations

Entry Information
Gene NameGLI pathogenesis-related 1
Protein EntryGLIP1_HUMAN
UniProt IDP48060
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48060-1; Sequence=Displayed; Name=2; Synonyms=RTVP-1b; IsoId=P48060-2; Sequence=VSP_043902; Note=Highly expressed in glioblastomas.;
Sequence CautionSequence=AAA82731.3; Type=Frameshift; Positions=3; Evidence={ECO:0000305};
SimilarityBelongs to the CRISP family. {ECO:0000305}.
SimilarityContains 1 SCP domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityAccording to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.
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