MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004444

Record overview

MGPD IDMGP004444
Gene ID11065
SpeciesHomo sapiens (Human)
Gene Nameubiquitin-conjugating enzyme E2C
Gene Symbol UBE2C
SynonymsUBCH10; dJ447F3.2;
Alternate namesubiquitin-conjugating enzyme E2 C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme; ubiquitin-protein ligase C;
Chromosome20
Map Location20q13.12
EC Number6.3.2.19
SummaryThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for UBE2C

Proteins

ubiquitin-conjugating enzyme E2 C isoform 1
Refseq ID:NP_008950
Protein GI:5902146
UniProt ID:O00762
mRNA ID:NM_007019
Length:179
RefSeq Status:
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLT
PCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
 
ubiquitin-conjugating enzyme E2 C isoform 2
Refseq ID:NP_861515
Protein GI:32967283
UniProt ID:O00762
mRNA ID:NM_181799
Length:161
RefSeq Status:
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTAVGSIRTSSTVCLLSGPRETQDSSKPLV
WGLGWDMRLLLELTLQLFLQMPEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
 
ubiquitin-conjugating enzyme E2 C isoform 3
Refseq ID:NP_861516
Protein GI:32967285
UniProt ID:O00762
mRNA ID:NM_181800
Length:150
RefSeq Status:
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVR
TILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
 
ubiquitin-conjugating enzyme E2 C isoform 4
Refseq ID:NP_861517
Protein GI:32967287
UniProt ID:O00762
mRNA ID:NM_181801
Length:140
RefSeq Status:
MTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLL
GEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
 
ubiquitin-conjugating enzyme E2 C isoform 6
Refseq ID:NP_001268670
Protein GI:528524529
UniProt ID:O00762
mRNA ID:NM_001281741
Length:132
RefSeq Status:
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMAVGSIRTSSTVCLLSGPRETQDSSKPLVWGLGWDMRLLLELTLQLFLQMPEPNIDSP
LNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
 
ubiquitin-conjugating enzyme E2 C isoform 7
Refseq ID:NP_001268671
Protein GI:528524532
UniProt ID:O00762
mRNA ID:NM_001281742
Length:79
RefSeq Status:
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTNPTLIVP
 
  logo