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MGP004444

Ontology/Pathway Information

Entrez Gene ID11065
Gene Nameubiquitin-conjugating enzyme E2C
Gene Symbol UBE2C
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005680 IDA:UniProtKBCanaphase-promoting complex
GO:0005737 IBA:GO_CentralCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0016881 IEA:InterProFacid-amino acid ligase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0019787 IBA:GO_CentralFsmall conjugating protein transferase activity
GO:0061631 IDA:MGIFubiquitin conjugating enzyme activity
GO:0061630 IBA:GO_CentralFubiquitin protein ligase activity
GO:0031625 IBA:GO_CentralFubiquitin protein ligase binding
GO:0004842 IDA:UniProtKBFubiquitin-protein transferase activity
GO:0051488 TAS:UniProtKBPactivation of anaphase-promoting complex activity
GO:0031145 IDA:UniProtKBPanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0008054 IDA:UniProtKBPcyclin catabolic process
GO:0010458 IMP:UniProtKBPexit from mitosis
GO:0010994 IDA:UniProtKBPfree ubiquitin chain polymerization
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007094 TAS:ReactomePmitotic spindle assembly checkpoint
GO:0051436 TAS:ReactomePnegative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0031536 IMP:UniProtKBPpositive regulation of exit from mitosis
GO:0051437 TAS:ReactomePpositive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979 IDA:UniProtKBPprotein K11-linked ubiquitination
GO:0070936 IDA:UniProtKBPprotein K48-linked ubiquitination
GO:0016567 IDA:UniProtKBPprotein ubiquitination
GO:0030071 IBA:GO_CentralPregulation of mitotic metaphase/anaphase transition
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0006511 IDA:UniProtKBPubiquitin-dependent protein catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6820APC/C:Cdc20 mediated degradation of Cyclin B
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_6871APC/C:Cdc20 mediated degradation of Securin
REACT_6761APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
REACT_267701APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
REACT_8017APC-Cdc20 mediated degradation of Nek2A
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_6785Autodegradation of Cdh1 by Cdh1:APC/C
REACT_6850Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_6867Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
REACT_6900Immune System
REACT_1072Inactivation of APC/C via direct inhibition of the APC/C complex
REACT_1041Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
REACT_1275Mitotic Anaphase
REACT_150314Mitotic Metaphase and Anaphase
REACT_2137Mitotic Spindle Checkpoint
REACT_910M Phase
REACT_6904Phosphorylation of the APC/C
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_21279Regulation of mitotic cell cycle
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_150471Separation of Sister Chromatids
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