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MGP004454

Record overview

MGPD IDMGP004454
Gene ID11112
SpeciesHomo sapiens (Human)
Gene Name3-hydroxyisobutyrate dehydrogenase
Gene Symbol HIBADH
SynonymsNS5ATP1;
Alternate names3-hydroxyisobutyrate dehydrogenase, mitochondrial; 3'-hydroxyisobutyrate dehydrogenase;
Chromosome7
Map Location7p15.2
EC Number1.1.1.31
SummaryThis gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]
OrthologsView orthologs and multiple alignments for HIBADH

Proteins

3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor
Refseq ID:NP_689953
Protein GI:23308751
UniProt ID:P31937
mRNA ID:NM_152740
Length:336
RefSeq Status:
MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRII
TMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCG
AVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI
LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF
 
transit_peptide: 1..36
experiment: experimental evidence, no additional details recorded
note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P31937.2)
calculated_mol_wt: 3809
peptide sequence: 
MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSV

mat_peptide: 37..336
product: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P31937.2)
calculated_mol_wt: 31538
peptide sequence: 
ASKTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTID
PAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLD
PKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF
 
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