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MGP004460

Record overview

MGPD IDMGP004460
Gene ID11130
SpeciesHomo sapiens (Human)
Gene NameZW10 interacting kinetochore protein
Gene Symbol ZWINT
SynonymsSIP30; ZWINT1; KNTC2AP; HZwint-1;
Alternate namesZW10 interactor; SNAP25 interacting protein of 30 kDa; ZW10 interactor, kinetochore protein; human ZW10 interacting protein-1; zwint-1;
Chromosome10
Map Location10q21-q22
SummaryThis gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ZWINT

Proteins

ZW10 interactor isoform a
Refseq ID:NP_127490
Protein GI:14602427
UniProt ID:O95229
mRNA ID:NM_032997
Length:277
RefSeq Status:
MEAAETEAEAAALEVLAEVAGILEPVGLQEEAELPAKILVEFVVDSQKKDKLLCSQLQVADFLQNILAQEDTAKGLDPLASEDTSRQKAIAAKEQWKELK
ATYREHVEAIKIGLTKALTQMEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQEKHLQHLAEVSAEVRERKTGTQQELDRVFQKLGNLKQQAE
QERDKLQRYQTFLQLLYTLQGKLLFPEAEAEAENLPDDKPQQPTRPQEQSTGDTMGRDPGVSFKAVGLQPAGDVNLP
 
ZW10 interactor isoform a
Refseq ID:NP_008988
Protein GI:14602429
UniProt ID:O95229
mRNA ID:NM_007057
Length:277
RefSeq Status:
Protein sequence is identical to GI:14602427 (mRNA isoform)
 
ZW10 interactor isoform b
Refseq ID:NP_001005413
Protein GI:53729320
UniProt ID:O95229
mRNA ID:NM_001005413
Length:230
RefSeq Status:
MEAAETEAEAAALEVLAEVAGILEPVGLQEEAELPAKILVEFVVDSQKKDKLLCSQLQVADFLQNILAQEDTAKGLDPLASEDTSRQKAIAAKEQWKELK
ATYREHVEAIKIGLTKALTQMEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQEKHLQHLAEVSAEGKLLFPEAEAEAENLPDDKPQQPTRPQ
EQSTGDTMGRDPGVSFKAVGLQPAGDVNLP
 
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