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MGP004460

UniProt Annotations

Entry Information
Gene NameZW10 interacting kinetochore protein
Protein EntryZWINT_HUMAN
UniProt IDO95229
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95229-1; Sequence=Displayed; Name=2; IsoId=O95229-2; Sequence=VSP_047660; Note=No experimental confirmation available.;
FunctionPart of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. {ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000269|PubMed:16732327}.
InteractionQ14457:BECN1; NbExp=6; IntAct=EBI-1001132, EBI-949378; O14777:NDC80; NbExp=11; IntAct=EBI-1001132, EBI-715849; O43264:ZW10; NbExp=6; IntAct=EBI-1001132, EBI-1001217;
Subcellular LocationNucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
SubunitInteracts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1. {ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:15824131, ECO:0000269|PubMed:16732327}.
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