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MGP004468

Record overview

MGPD IDMGP004468
Gene ID11164
SpeciesHomo sapiens (Human)
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 5
Gene Symbol NUDT5
SynonymsYSA1; YSA1H; YSAH1; hYSAH1;
Alternate namesADP-sugar pyrophosphatase; 8-oxo-dGDP phosphatase;
Chromosome10
Map Location10p14
EC Number3.6.1.13
SummaryThis gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for NUDT5

Proteins

ADP-sugar pyrophosphatase
Refseq ID:NP_054861
Protein GI:37594464
UniProt ID:Q9UKK9
mRNA ID:NM_014142
Length:219
RefSeq Status:
MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTADGVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLID
DGETPEAAALRELEEETGYKGDIAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKPGDGEFVEVISLPKNDLLQRLDALVAEEHLTVDARVYSY
ALALKHANAKPFEVPFLKF
 
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