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MGP004468

UniProt Annotations

Entry Information
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 5
Protein EntryNUDT5_HUMAN
UniProt IDQ9UKK9
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate. {ECO:0000269|PubMed:17052728}.
Catalytic ActivityADP-D-ribose + H(2)O = AMP + D-ribose 5- phosphate. {ECO:0000269|PubMed:17052728}.
Catalytic ActivityADP-sugar + H(2)O = AMP + alpha-D-aldose 5- phosphate. {ECO:0000269|PubMed:17052728}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755};
FunctionHydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:17052728}.
SimilarityBelongs to the Nudix hydrolase family. {ECO:0000305}.
SimilarityContains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule:PRU00794}.
SubunitHomodimer. {ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755}.
Tissue SpecificityWidely expressed. Most abundant in liver.
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