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MGP004476

UniProt Annotations

Entry Information
Gene Nameindolethylamine N-methyltransferase
Protein EntryINMT_HUMAN
UniProt IDO95050
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95050-1; Sequence=Displayed; Name=2; IsoId=O95050-2; Sequence=VSP_045922; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=2.9 mM for tryptamine {ECO:0000269|PubMed:10552930};
Catalytic ActivityS-adenosyl-L-methionine + an amine = S- adenosyl-L-homocysteine + a methylated amine. {ECO:0000269|PubMed:10552930}.
Catalytic ActivityS-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. {ECO:0000269|PubMed:10552930}.
FunctionFunctions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. {ECO:0000250, ECO:0000269|PubMed:10552930}.
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityWidely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain. {ECO:0000269|PubMed:10552930}.
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