MGP Database

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MGP004481

Ontology/Pathway Information

Entrez Gene ID11213
Gene Nameinterleukin-1 receptor-associated kinase 3
Gene Symbol IRAK3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0045323 IBA:GO_CentralCinterleukin-1 receptor complex
GO:0005634 IDA:BHF-UCLCnucleus
GO:0005524 IDA:UniProtKBFATP binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0046982 IPI:BHF-UCLFprotein heterodimerization activity
GO:0042803 IPI:BHF-UCLFprotein homodimerization activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0019221 ISS:UniProtKBPcytokine-mediated signaling pathway
GO:0070498 IMP:BHF-UCLPinterleukin-1-mediated signaling pathway
GO:0002755 TAS:BHF-UCLPMyD88-dependent toll-like receptor signaling pathway
GO:0001960 IC:BHF-UCLPnegative regulation of cytokine-mediated signaling pathway
GO:0045824 ISS:BHF-UCLPnegative regulation of innate immune response
GO:0032695 IMP:BHF-UCLPnegative regulation of interleukin-12 production
GO:0032715 IMP:BHF-UCLPnegative regulation of interleukin-6 production
GO:0010936 ISS:BHF-UCLPnegative regulation of macrophage cytokine production
GO:0043407 IMP:BHF-UCLPnegative regulation of MAP kinase activity
GO:0032088 IMP:BHF-UCLPnegative regulation of NF-kappaB transcription factor activity
GO:0042177 IMP:BHF-UCLPnegative regulation of protein catabolic process
GO:0043242 IMP:BHF-UCLPnegative regulation of protein complex disassembly
GO:0034122 ISS:BHF-UCLPnegative regulation of toll-like receptor signaling pathway
GO:0032720 IMP:BHF-UCLPnegative regulation of tumor necrosis factor production
GO:0010933 ISS:BHF-UCLPpositive regulation of macrophage tolerance induction
GO:0051092 IMP:BHF-UCLPpositive regulation of NF-kappaB transcription factor activity
GO:0046777 IEA:EnsemblPprotein autophosphorylation
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0043244 ISS:UniProtKBPregulation of protein complex disassembly
GO:0043330 ISS:BHF-UCLPresponse to exogenous dsRNA
GO:0070555 IMP:BHF-UCLPresponse to interleukin-1
GO:0032496 ISS:BHF-UCLPresponse to lipopolysaccharide
GO:0032494 ISS:BHF-UCLPresponse to peptidoglycan
GO:0009615 IC:BHF-UCLPresponse to virus
GO:0002224 IBA:GO_CentralPtoll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22442Interleukin-1 signaling
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_22232Signaling by Interleukins
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
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