MGP Database

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MGP004481

UniProt Annotations

Entry Information
Gene Nameinterleukin-1 receptor-associated kinase 3
Protein EntryIRAK3_HUMAN
UniProt IDQ9Y616
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y616-1; Sequence=Displayed; Name=2; IsoId=Q9Y616-2; Sequence=VSP_041020; Note=No experimental confirmation available.;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:10383454}.
CautionSer-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed:10383454, while other authors describe this as an inactive kinase. {ECO:0000305}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10383454};
DiseaseAsthma-related traits 5 (ASRT5) [MIM:611064]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269|PubMed:17503328}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionInhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. {ECO:0000250|UniProtKB:Q8K4B2}.
SimilarityBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. {ECO:0000305}.
SimilarityContains 1 death domain. {ECO:0000255|PROSITE- ProRule:PRU00064}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Tissue SpecificityExpressed predominantly in peripheral blood lymphocytes. {ECO:0000269|PubMed:10383454}.
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