MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004502

Record overview

MGPD IDMGP004502
Gene ID11283
SpeciesHomo sapiens (Human)
Gene Namecytochrome P450, family 4, subfamily F, polypeptide 8
Gene Symbol CYP4F8
SynonymsCPF8; CYPIVF8;
Alternate namescytochrome P450 4F8; cytochrome P450, subfamily IVF, polypeptide 8; flavoprotein-linked monooxygenase; microsomal monooxygenase;
Chromosome19
Map Location19p13.1
EC Number1.14.14.1
SummaryThis gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CYP4F8

Proteins

cytochrome P450 4F8 precursor
Refseq ID:NP_009184
Protein GI:6005737
UniProt ID:P98187
mRNA ID:NM_007253
Length:520
RefSeq Status:
MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIIN
LCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTL
DSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFAR
GCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRR
TPEIVLRAEDGLWLRVEPLG
 
sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1714
peptide sequence: 
MSLLSLSWLGLRPVAA
 
  logo