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MGP004551

Record overview

MGPD IDMGP004551
Gene ID22943
SpeciesHomo sapiens (Human)
Gene Namedickkopf WNT signaling pathway inhibitor 1
Gene Symbol DKK1
SynonymsSK; DKK-1;
Alternate namesdickkopf-related protein 1; dickkopf 1 homolog; dickkopf related protein-1; dickkopf-1 like; dickkopf-like protein 1; hDkk-1;
Chromosome10
Map Location10q11.2
SummaryThis gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DKK1

Proteins

dickkopf-related protein 1 precursor
Refseq ID:NP_036374
Protein GI:7110719
UniProt ID:O94907
mRNA ID:NM_012242
Length:266
RefSeq Status:
MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASP
TRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLC
CARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
 
sig_peptide: 1..31
calculated_mol_wt: 2912
peptide sequence: 
MMALGAAGATRVFVAMVAAALGGHPLLGVSA

mat_peptide: 32..266
product: dickkopf-related protein 1
calculated_mol_wt: 25778
peptide sequence: 
TLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGN
YCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGL
EIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
 
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