MGP Database

MGP004551

Ontology/Pathway Information

Entrez Gene ID	22943
Gene Name	dickkopf WNT signaling pathway inhibitor 1
Gene Symbol	DKK1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005615	IDA:BHF-UCL	C	extracellular space
GO:0005886	IDA:MGI	C	plasma membrane
GO:0008083	TAS:ProtInc	F	growth factor activity
GO:0050750	IDA:MGI	F	low-density lipoprotein particle receptor binding
GO:0048019	IDA:BHF-UCL	F	receptor antagonist activity
GO:0004871	TAS:ProtInc	F	signal transducer activity
GO:0000904	IEA:Ensembl	P	cell morphogenesis involved in differentiation
GO:0030326	IEA:Ensembl	P	embryonic limb morphogenesis
GO:0001706	IEA:Ensembl	P	endoderm formation
GO:1900116	IDA:GOC	P	extracellular negative regulation of signal transduction
GO:0060325	IEA:Ensembl	P	face morphogenesis
GO:0030900	IEA:Ensembl	P	forebrain development
GO:0001942	IEA:Ensembl	P	hair follicle development
GO:0001707	IEA:Ensembl	P	mesoderm formation
GO:0030514	IEA:Ensembl	P	negative regulation of BMP signaling pathway
GO:0090090	IDA:BHF-UCL	P	negative regulation of canonical Wnt signaling pathway
GO:1901296	IDA:BHF-UCL	P	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:2000726	IDA:BHF-UCL	P	negative regulation of cardiac muscle cell differentiation
GO:0042662	IDA:BHF-UCL	P	negative regulation of mesodermal cell fate specification
GO:0060394	IDA:BHF-UCL	P	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0033137	IDA:BHF-UCL	P	negative regulation of peptidyl-serine phosphorylation
GO:0031333	IDA:BHF-UCL	P	negative regulation of protein complex assembly
GO:0048642	IEA:Ensembl	P	negative regulation of skeletal muscle tissue development
GO:0000122	IDA:BHF-UCL	P	negative regulation of transcription from RNA polymerase II promoter
GO:0030178	IDA:UniProtKB	P	negative regulation of Wnt signaling pathway
GO:0090082	ISS:BHF-UCL	P	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
GO:0042663	IDA:BHF-UCL	P	regulation of endodermal cell fate specification
GO:0002090	IDA:BHF-UCL	P	regulation of receptor internalization
GO:0032526	IEA:Ensembl	P	response to retinoic acid
GO:0090244	IEA:Ensembl	P	Wnt signaling pathway involved in somitogenesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116125	Disease
REACT_264594	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264383	negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_264378	RNF mutants show enhanced WNT signaling and proliferation
REACT_11045	Signaling by Wnt
REACT_264125	Signaling by WNT in cancer
REACT_111102	Signal Transduction
REACT_264596	TCF dependent signaling in response to WNT
REACT_264356	XAV939 inhibits tankyrase, stabilizing AXIN