MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004611

UniProt Annotations

Entry Information
Gene Namedeltex 4, E3 ubiquitin ligase
Protein EntryDTX4_HUMAN
UniProt IDQ9Y2E6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y2E6-1; Sequence=Displayed; Name=2; IsoId=Q9Y2E6-2; Sequence=VSP_023784;
DomainThe WWE domains are thought to mediate some protein- protein interaction, and are frequently found in ubiquitin ligases. {ECO:0000250}.
FunctionRegulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}.
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=BAA76781.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the Deltex family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
SimilarityContains 2 WWE domains. {ECO:0000255|PROSITE- ProRule:PRU00248}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitInteracts with NLRP4. {ECO:0000269|PubMed:22388039}.
  logo