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MGP004660

UniProt Annotations

Entry Information
Gene Namesirtuin 3
Protein EntrySIR3_HUMAN
UniProt IDQ9NTG7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NTG7-1; Sequence=Displayed; Name=2; IsoId=Q9NTG7-2; Sequence=VSP_043792;
Biophysicochemical PropertiesKinetic parameters: KM=600 uM for NAD {ECO:0000269|PubMed:19535340};
Catalytic ActivityNAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. {ECO:0000255|PROSITE- ProRule:PRU00236, ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16788062}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
FunctionNAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090}.
InteractionP25705:ATP5A1; NbExp=2; IntAct=EBI-724621, EBI-351437; Q13309:SKP2; NbExp=5; IntAct=EBI-724621, EBI-456291;
MiscellaneousHas some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo.
PtmProcessed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity. {ECO:0000269|PubMed:12186850}.
SimilarityBelongs to the sirtuin family. Class I subfamily. {ECO:0000305}.
SimilarityContains 1 deacetylase sirtuin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00236}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119}.
SubunitInteracts with NDUFA9, ACSS1, IDH2 and GDH. {ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}.
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