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MGP004680

Record overview

MGPD IDMGP004680
Gene ID23464
SpeciesHomo sapiens (Human)
Gene Nameglycine C-acetyltransferase
Gene Symbol GCAT
SynonymsKBL;
Alternate names2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; 2-amino-3-ketobutyrate-CoA ligase; AKB ligase; aminoacetone synthase; glycine acetyltransferase;
Chromosome22
Map Location22q13.1
EC Number2.3.1.29
SummaryThe degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
OrthologsView orthologs and multiple alignments for GCAT

Proteins

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform 1 precursor
Refseq ID:NP_001165161
Protein GI:284448556
UniProt ID:O75600
mRNA ID:NM_001171690
Length:445
RefSeq Status:
MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGPGTVIFPGLPLPHLSCCIHLLSFTSGILNFCANN
YLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKY
RYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGY
TTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVI
GFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP
 
transit_peptide: 1..21
inference: protein motif:TargetP:1.1
note: The cleavage site of the transit peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction
calculated_mol_wt: 2527
peptide sequence: 
MWPGNAWRAALFWVPRGRRAQ

mat_peptide: 22..419
product: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform 2
calculated_mol_wt: 42776
peptide sequence: 
SALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIAR
FHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLA
SRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQ
SMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP

transit_peptide: 1..21
inference: protein motif:TargetP:1.1
note: The cleavage site of the transit peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction
calculated_mol_wt: 2527
peptide sequence: 
MWPGNAWRAALFWVPRGRRAQ

mat_peptide: 22..445
product: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform 1
calculated_mol_wt: 45466
peptide sequence: 
SALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGPGTVIFPGLPLPHLSCCIHLLSFTSGILNFCANNYLGLSSHPEVIQAGLQALEEF
GAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHR
LRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFS
NSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAV
HSEEDIDRCVEAFVEVGRLHGALP
 
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform 2 precursor
Refseq ID:NP_055106
Protein GI:7657118
UniProt ID:O75600
mRNA ID:NM_014291
Length:419
RefSeq Status:
MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLS
SVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVA
TDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPP
AVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEED
IDRCVEAFVEVGRLHGALP
 
transit_peptide: 1..21
inference: protein motif:TargetP:1.1
note: The cleavage site of the transit peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction
calculated_mol_wt: 2527
peptide sequence: 
MWPGNAWRAALFWVPRGRRAQ

mat_peptide: 22..419
product: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform 2
calculated_mol_wt: 42776
peptide sequence: 
SALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIAR
FHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLA
SRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQ
SMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP
 
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