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MGP004680

UniProt Annotations

Entry Information
Gene Nameglycine C-acetyltransferase
Protein EntryKBL_HUMAN
UniProt IDO75600
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75600-1; Sequence=Displayed; Name=2; IsoId=O75600-2; Sequence=VSP_044607; Note=Ref.2 (BAC85552) sequence is in conflict in position: 77:L->S. No experimental confirmation available. {ECO:0000305};
Catalytic ActivityAcetyl-CoA + glycine = CoA + 2-amino-3- oxobutanoate.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
PathwayAmino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.
Sequence CautionSequence=BAC85552.1; Type=Frameshift; Positions=232; Evidence={ECO:0000305};
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17688197}. Note=Translocates to the nucleus upon cold and osmotic stress.
Tissue SpecificityStrongly expressed in heart, brain, liver and pancreas. Also found in lung. {ECO:0000269|PubMed:10712613}.
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