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MGP004682

UniProt Annotations

Entry Information
Gene Namechromobox homolog 5
Protein EntryCBX5_HUMAN
UniProt IDP45973
SpeciesHuman
Comments
Comment typeDescription
FunctionComponent of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. {ECO:0000269|PubMed:19783980}.
InteractionQ9H2P0:ADNP; NbExp=2; IntAct=EBI-78219, EBI-1764854; Q8IXJ9:ASXL1; NbExp=2; IntAct=EBI-78219, EBI-1646500; P59598:Asxl1 (xeno); NbExp=5; IntAct=EBI-78219, EBI-5743705; P46100:ATRX; NbExp=2; IntAct=EBI-78219, EBI-396461; Q13111:CHAF1A; NbExp=7; IntAct=EBI-78219, EBI-1020839; P84243:H3F3B; NbExp=2; IntAct=EBI-78219, EBI-120658; P68431:HIST1H3D; NbExp=9; IntAct=EBI-78219, EBI-79722; Q9NQS7:INCENP; NbExp=6; IntAct=EBI-78219, EBI-307907; Q14739:LBR; NbExp=4; IntAct=EBI-78219, EBI-1055147; Q5ZUS4:legAS4 (xeno); NbExp=6; IntAct=EBI-78219, EBI-8871796; Q9UIS9:MBD1; NbExp=6; IntAct=EBI-78219, EBI-867196; Q7Z3K3:POGZ; NbExp=6; IntAct=EBI-78219, EBI-1389308; Q9BQF6:SENP7; NbExp=2; IntAct=EBI-78219, EBI-766251; O43463:SUV39H1; NbExp=3; IntAct=EBI-78219, EBI-349968; Q13263:TRIM28; NbExp=9; IntAct=EBI-78219, EBI-78139;
PtmPhosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper- phosphorylated during mitosis. {ECO:0000250, ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}.
PtmUbiquitinated. {ECO:0000269|PubMed:20498703}.
SimilarityContains 2 chromo domains. {ECO:0000255|PROSITE- ProRule:PRU00053}.
Subcellular LocationNucleus {ECO:0000269|PubMed:10460410}. Chromosome {ECO:0000269|PubMed:10460410}. Chromosome, centromere {ECO:0000269|PubMed:10460410}. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
SubunitInteracts with SUV420H1 and SUV420H2 (By similarity). Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1. {ECO:0000250, ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:11313457, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:15864296, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:15899859, ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:19880879, ECO:0000269|PubMed:20042602, ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21047797, ECO:0000269|PubMed:9169472}.
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