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MGP004685

Record overview

MGPD IDMGP004685
Gene ID23475
SpeciesHomo sapiens (Human)
Gene Namequinolinate phosphoribosyltransferase
Gene Symbol QPRT
SynonymsQPRTase; HEL-S-90n;
Alternate namesnicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating);
Chromosome16
Map Location16p11.2
EC Number2.4.2.19
SummaryThis gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for QPRT

Proteins

nicotinate-nucleotide pyrophosphorylase [carboxylating] precursor
Refseq ID:NP_055113
Protein GI:45269149
UniProt ID:Q15274
mRNA ID:NM_014298
Length:297
RefSeq Status:
MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLG
ERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEV
ECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
 
sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1624
peptide sequence: 
MDAEGLALLLPPVTLA
 
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