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MGP004685

UniProt Annotations

Entry Information
Gene Namequinolinate phosphoribosyltransferase
Protein EntryNADC_HUMAN
UniProt IDQ15274
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP) {ECO:0000269|PubMed:17868694}; KM=23 uM for QA (at 0.3 mM PRPP) {ECO:0000269|PubMed:17868694}; Vmax=1.2 uM/min/mg enzyme (at 0.3 mM QA and 0.1 mM PRPP) {ECO:0000269|PubMed:17868694}; Vmax=0.93 uM/min/mg enzyme (at 0.3 mM QA and 0.3 mM PRPP) {ECO:0000269|PubMed:17868694};
Catalytic ActivityBeta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1- diphosphate.
Enzyme RegulationActivity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner. {ECO:0000269|PubMed:17868694}.
FunctionInvolved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694}.
PathwayCofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from quinolinate: step 1/1.
SimilarityBelongs to the NadC/ModD family. {ECO:0000305}.
SubunitHexamer formed by 3 homodimers. {ECO:0000269|PubMed:17868694}.
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