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MGP004689

Record overview

MGPD IDMGP004689
Gene ID23498
SpeciesHomo sapiens (Human)
Gene Name3-hydroxyanthranilate 3,4-dioxygenase
Gene Symbol HAAO
SynonymsHAO; 3-HAO;
Alternate names3-hydroxyanthranilate 3,4-dioxygenase; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAAO; HAD;
Chromosome2
Map Location2p21
EC Number1.13.11.6
Summary3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HAAO

Proteins

3-hydroxyanthranilate 3,4-dioxygenase
Refseq ID:NP_036337
Protein GI:188497625
UniProt ID:P46952
mRNA ID:NM_012205
Length:286
RefSeq Status:
MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTV
GLVVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQAGTPL
SLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVTMGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG
 
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