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MGP004689

UniProt Annotations

Entry Information
Gene Name3-hydroxyanthranilate 3,4-dioxygenase
Protein Entry3HAO_HUMAN
UniProt IDP46952
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P46952-1; Sequence=Displayed; Name=2; IsoId=P46952-2; Sequence=VSP_036239;
Catalytic Activity3-hydroxyanthranilate + O(2) = 2-amino-3- carboxymuconate semialdehyde. {ECO:0000255|HAMAP-Rule:MF_03019, ECO:0000269|PubMed:7514594}.
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000255|HAMAP-Rule:MF_03019, ECO:0000269|PubMed:7514594};
FunctionCatalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {ECO:0000255|HAMAP- Rule:MF_03019, ECO:0000269|PubMed:7514594}.
PathwayCofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. {ECO:0000255|HAMAP-Rule:MF_03019}.
SimilarityBelongs to the 3-HAO family. {ECO:0000255|HAMAP- Rule:MF_03019}.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO:0000255|HAMAP-Rule:MF_03019, ECO:0000269|Ref.8}.
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