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MGP004735

Record overview

MGPD IDMGP004735
Gene ID23659
SpeciesHomo sapiens (Human)
Gene Namephospholipase A2, group XV
Gene Symbol PLA2G15
SynonymsACS; LLPL; LPLA2; LYPLA3; GXVPLA2;
Alternate namesgroup XV phospholipase A2; 1-O-acylceramide synthase; LCAT-like lysophospholipase; lysophospholipase 3 (lysosomal phospholipase A2); lysosomal phospholipase A2;
Chromosome16
Map Location16q22.1
EC Number2.3.1.-
SummaryLysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PLA2G15

Proteins

group XV phospholipase A2 precursor
Refseq ID:NP_036452
Protein GI:6912484
UniProt ID:Q8NCC3
mRNA ID:NM_012320
Length:412
RefSeq Status:
MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALPAGRHPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNK
TSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMG
NMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQ
DIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANAT
TLAYLKRVLLGP
 
sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3656
peptide sequence: 
MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALP
 
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