MGP Database

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MGP004735

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group XV
Protein EntryPAG15_HUMAN
UniProt IDQ8NCC3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NCC3-1; Sequence=Displayed; Name=2; IsoId=Q8NCC3-2; Sequence=VSP_056689, VSP_056690; Note=No experimental confirmation available.;
FunctionHas transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity. {ECO:0000250}.
PtmN-glycosylated. {ECO:0000269|PubMed:11790796}.
Sequence CautionSequence=CAB53675.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular LocationLysosome {ECO:0000250}. Secreted {ECO:0000269|PubMed:10092508}.
Tissue SpecificityHighly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:10092508}.
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