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MGP004743

Record overview

MGPD IDMGP004743
Gene ID23764
SpeciesHomo sapiens (Human)
Gene Namev-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
Gene Symbol MAFF
SynonymsU-MAF; hMafF;
Alternate namestranscription factor MafF; v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F;
Chromosome22
Map Location22q13.1
SummaryThe protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
OrthologsView orthologs and multiple alignments for MAFF

Proteins

transcription factor MafF isoform a
Refseq ID:NP_001155044
Protein GI:239048350
UniProt ID:Q9ULX9
mRNA ID:NM_001161572
Length:164
RefSeq Status:
MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLKNRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAM
RLELDALRGKCEALQGFARSVAAARGPATLVAPASVITIVKSTPGSGSGPAHGPDPAHGPASCS
 
transcription factor MafF isoform a
Refseq ID:NP_036455
Protein GI:6912490
UniProt ID:Q9ULX9
mRNA ID:NM_012323
Length:164
RefSeq Status:
Protein sequence is identical to GI:239048350 (mRNA isoform)
 
transcription factor MafF isoform a
Refseq ID:NP_001155045
Protein GI:239048388
UniProt ID:Q9ULX9
mRNA ID:NM_001161573
Length:164
RefSeq Status:
Protein sequence is identical to GI:239048350 (mRNA isoform)
 
transcription factor MafF isoform b
Refseq ID:NP_001155046
Protein GI:239048390
UniProt ID:Q9ULX9
mRNA ID:NM_001161574
Length:135
RefSeq Status:
MGLSVRELNRHLRGLSAEEVTRLKQRRRTLKNRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARSVAAARGPAT
LVAPASVITIVKSTPGSGSGPAHGPDPAHGPASCS
 
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