MGP Database

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MGP004743

UniProt Annotations

Entry Information
Gene Namev-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
Protein EntryMAFF_HUMAN
UniProt IDQ9ULX9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULX9-1; Sequence=Displayed; Name=2; IsoId=Q9ULX9-2; Sequence=VSP_043029; Note=No experimental confirmation available.;
FunctionInteracts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.
InductionBy oxidative stress. {ECO:0000269|PubMed:11772409}.
SimilarityBelongs to the bZIP family. Maf subfamily. {ECO:0000305}.
SimilarityContains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255|PROSITE-ProRule:PRU00978}.
Subcellular LocationNucleus.
SubunitMonomer and homo- or heterodimer. Interacts with MIP. {ECO:0000269|PubMed:16549056}.
Tissue SpecificityExpressed in the term myometrium and kidney.
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