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MGP004820

Record overview

MGPD IDMGP004820
Gene ID26190
SpeciesHomo sapiens (Human)
Gene NameF-box and WD repeat domain containing 2
Gene Symbol FBXW2
SynonymsMd6; FBW2; Fwd2;
Alternate namesF-box/WD repeat-containing protein 2; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2;
Chromosome9
Map Location9q34
SummaryF-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FBXW2

Proteins

F-box/WD repeat-containing protein 2
Refseq ID:NP_036296
Protein GI:118402584
UniProt ID:Q9UKT8
mRNA ID:NM_012164
Length:454
RefSeq Status:
MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQT
ACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLV
TGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE
IKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISR
WPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG
 
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